Symptoms of Peripheral Artery Disease: Reduced blood flow as a result of narrowing or occlusion of the vessels in the legs and sometimes in the arms. Peripheral artery disease causes symptoms such as pain, fatigue, and numbness in the legs. Peripheral artery disease occurs when the arteries that carry blood to distant parts of your body narrow. This condition leads to reduced blood flow and various symptoms. PAH usually occurs due to atherosclerosis...