What is Buerger's Disease? Buerger's disease, a peripheral vascular disease, occurs as a result of progressive blockage in the veins of the hands and feet due to smoking. Buerger's disease occurs as a result of excessive use of cigarettes and tobacco products. The disease occurs in the arteries and veins of the arms and legs. In Buerger's disease, vascular occlusion occurs due to inflammation and swelling of the blood vessels and the formation of blood clots. This...